Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
**
Top Medical Research Studies
9.5
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Read More
9
CoQ10 shows promise for autoimmune treatment
We explored the effects of coenzyme Q10 (CoQ10) as a treatment for various autoimmune disorders. Over a period from 1966 to April 2023, we reviewed 20 articles encompassing a total of 483 patients, focusing on conditions such as Fibromyalgia (FM), Rheumatoid Arthritis (RA), and Antiphospholipid Syndrome (APS).
Our findings revealed that CoQ10 supplementation resulted in notable improvements, especially for patients with RA. Specifically, these patients showed enhancements in disease activity index and reductions in inflammatory markers, including erythrocyte sedimentation rate and malondialdehyde levels. For those with APS, CoQ10 exhibited benefits such as improved endothelial function and reduced pro-inflammatory markers.
When it came to FM, most studies indicated that individuals experienced relief in symptoms related to pain, fatigue, sleep disturbances, and mood disorders. Notably, the treatment was well-received, with only minor side effects reported in a couple of cases.
Overall, CoQ10 appears to be an effective complementary treatment option for patients suffering from RA and FM. However, we encourage further research involving larger sample sizes and additional autoimmune conditions to better understand its efficacy.
Our findings revealed that CoQ10 supplementation resulted in notable improvements, especially for patients with RA. Specifically, these patients showed enhancements in disease activity index and reductions in inflammatory markers, including erythrocyte sedimentation rate and malondialdehyde levels. For those with APS, CoQ10 exhibited benefits such as improved endothelial function and reduced pro-inflammatory markers.
When it came to FM, most studies indicated that individuals experienced relief in symptoms related to pain, fatigue, sleep disturbances, and mood disorders. Notably, the treatment was well-received, with only minor side effects reported in a couple of cases.
Overall, CoQ10 appears to be an effective complementary treatment option for patients suffering from RA and FM. However, we encourage further research involving larger sample sizes and additional autoimmune conditions to better understand its efficacy.
Read More
9
CoQ10 improves rheumatoid arthritis symptoms
We conducted a randomized, double-blind, placebo-controlled trial to investigate the potential benefits of coenzyme Q10 (CoQ10) supplementation for individuals with rheumatoid arthritis (RA). Our group included 54 participants who were assigned to receive either 100 mg of CoQ10 or a placebo daily for two months. We carefully measured changes in serum matrix metalloproteinases (MMPs), as well as clinical parameters like the Disease Activity Score in 28 joints (DAS-28) before and after the treatment period.
The results were quite promising. We observed that CoQ10 significantly reduced the level of MMP-3 and improved various clinical outcomes—showing a notable drop in DAS-28 scores which indicates reduced disease activity. Furthermore, patients taking CoQ10 experienced significant reductions in swollen and tender joint counts, pain scores, and erythrocyte sedimentation rate (ESR) compared to their initial readings.
Overall, the findings suggest that CoQ10 supplementation may complement standard treatments for rheumatoid arthritis, helping to reduce inflammation and improve joint health. This new approach could offer hope for RA patients looking for additional management options.
The results were quite promising. We observed that CoQ10 significantly reduced the level of MMP-3 and improved various clinical outcomes—showing a notable drop in DAS-28 scores which indicates reduced disease activity. Furthermore, patients taking CoQ10 experienced significant reductions in swollen and tender joint counts, pain scores, and erythrocyte sedimentation rate (ESR) compared to their initial readings.
Overall, the findings suggest that CoQ10 supplementation may complement standard treatments for rheumatoid arthritis, helping to reduce inflammation and improve joint health. This new approach could offer hope for RA patients looking for additional management options.
Read More
Most Useful Reviews
7.5
Boosts energy
Excellent! I discovered IHERB products six months ago and now regularly order D3, also known as the solar vitamin. The small gelatin capsules are easy to take, and I drink two each morning. I've experienced no side effects during my use, and I've begun to feel much better overall, with increased vivacity and energy.
Read More
2
No visible results
I took the course but didn't see any noticeable effect, so I've decided to order from another company.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
- All Researches
9.5
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Read More
9
CoQ10 shows promise for autoimmune treatment
We explored the effects of coenzyme Q10 (CoQ10) as a treatment for various autoimmune disorders. Over a period from 1966 to April 2023, we reviewed 20 articles encompassing a total of 483 patients, focusing on conditions such as Fibromyalgia (FM), Rheumatoid Arthritis (RA), and Antiphospholipid Syndrome (APS).
Our findings revealed that CoQ10 supplementation resulted in notable improvements, especially for patients with RA. Specifically, these patients showed enhancements in disease activity index and reductions in inflammatory markers, including erythrocyte sedimentation rate and malondialdehyde levels. For those with APS, CoQ10 exhibited benefits such as improved endothelial function and reduced pro-inflammatory markers.
When it came to FM, most studies indicated that individuals experienced relief in symptoms related to pain, fatigue, sleep disturbances, and mood disorders. Notably, the treatment was well-received, with only minor side effects reported in a couple of cases.
Overall, CoQ10 appears to be an effective complementary treatment option for patients suffering from RA and FM. However, we encourage further research involving larger sample sizes and additional autoimmune conditions to better understand its efficacy.
Our findings revealed that CoQ10 supplementation resulted in notable improvements, especially for patients with RA. Specifically, these patients showed enhancements in disease activity index and reductions in inflammatory markers, including erythrocyte sedimentation rate and malondialdehyde levels. For those with APS, CoQ10 exhibited benefits such as improved endothelial function and reduced pro-inflammatory markers.
When it came to FM, most studies indicated that individuals experienced relief in symptoms related to pain, fatigue, sleep disturbances, and mood disorders. Notably, the treatment was well-received, with only minor side effects reported in a couple of cases.
Overall, CoQ10 appears to be an effective complementary treatment option for patients suffering from RA and FM. However, we encourage further research involving larger sample sizes and additional autoimmune conditions to better understand its efficacy.
Read More
9
In a comprehensive study, we explored the potential benefits of Coenzyme Q10 (CoQ10) in addressing the challenges of Multiple Sclerosis (MS), a chronic autoimmune disorder that leads to the degradation of protective myelin in the central nervous system. Using a well-established mouse model, we divided the animals into groups—some receiving a diet containing cuprizone (CPZ) to induce MS symptoms, while one group was also given CoQ10 to assess its impact on demyelination and remyelination.
Over a period of 12 weeks, the effects of CoQ10 were assessed through behavioral tests and molecular analyses. We noted improvements in the histological results for those treated with CoQ10, including increased levels of myelin basic protein and specific markers that indicate support for oligodendrocyte health. These findings suggest that CoQ10 administration can significantly promote remyelination and reduce oxidative stress and inflammation linked to CPZ exposure.
While the CPZ group did not exhibit significant differences in behavioral tests compared to controls, the positive cellular and histological outcomes demonstrated the treatment's promise. Overall, our findings could imply that CoQ10 might be beneficial in managing remyelination processes in MS, although further research in human subjects is needed to fully understand its potential.
Over a period of 12 weeks, the effects of CoQ10 were assessed through behavioral tests and molecular analyses. We noted improvements in the histological results for those treated with CoQ10, including increased levels of myelin basic protein and specific markers that indicate support for oligodendrocyte health. These findings suggest that CoQ10 administration can significantly promote remyelination and reduce oxidative stress and inflammation linked to CPZ exposure.
While the CPZ group did not exhibit significant differences in behavioral tests compared to controls, the positive cellular and histological outcomes demonstrated the treatment's promise. Overall, our findings could imply that CoQ10 might be beneficial in managing remyelination processes in MS, although further research in human subjects is needed to fully understand its potential.
Read More
9
We explored the anti-inflammatory effects of Coenzyme Q10 (CoQ10) using liposome/gold hybrid nanoparticles, referred to as LGNP-CoQ10, specifically in the context of rheumatoid arthritis. The study involved administering both CoQ10 and LGNP-CoQ10 orally to mice suffering from collagen-induced arthritis (CIA) over a period of 10 weeks.
To understand the impact, we analyzed the joint tissues for inflammation pathology and also looked closely at the immune response through various staining techniques. Our findings revealed a notable decrease in pro-inflammatory cytokines and populations of Th17 cells, which are commonly associated with autoimmune responses, in the mice treated with LGNP-CoQ10.
Additionally, when we tested human peripheral blood mononuclear cells, we observed that the IL-17 expression significantly dropped when treated with the LGNP-CoQ10 formulation. This suggests that the hybrid nanoparticle approach effectively enhances the anti-inflammatory properties of CoQ10, indicating its potential as a therapeutic option for rheumatoid arthritis.
To understand the impact, we analyzed the joint tissues for inflammation pathology and also looked closely at the immune response through various staining techniques. Our findings revealed a notable decrease in pro-inflammatory cytokines and populations of Th17 cells, which are commonly associated with autoimmune responses, in the mice treated with LGNP-CoQ10.
Additionally, when we tested human peripheral blood mononuclear cells, we observed that the IL-17 expression significantly dropped when treated with the LGNP-CoQ10 formulation. This suggests that the hybrid nanoparticle approach effectively enhances the anti-inflammatory properties of CoQ10, indicating its potential as a therapeutic option for rheumatoid arthritis.
Read More
9
CoQ10 improves rheumatoid arthritis symptoms
We conducted a randomized, double-blind, placebo-controlled trial to investigate the potential benefits of coenzyme Q10 (CoQ10) supplementation for individuals with rheumatoid arthritis (RA). Our group included 54 participants who were assigned to receive either 100 mg of CoQ10 or a placebo daily for two months. We carefully measured changes in serum matrix metalloproteinases (MMPs), as well as clinical parameters like the Disease Activity Score in 28 joints (DAS-28) before and after the treatment period.
The results were quite promising. We observed that CoQ10 significantly reduced the level of MMP-3 and improved various clinical outcomes—showing a notable drop in DAS-28 scores which indicates reduced disease activity. Furthermore, patients taking CoQ10 experienced significant reductions in swollen and tender joint counts, pain scores, and erythrocyte sedimentation rate (ESR) compared to their initial readings.
Overall, the findings suggest that CoQ10 supplementation may complement standard treatments for rheumatoid arthritis, helping to reduce inflammation and improve joint health. This new approach could offer hope for RA patients looking for additional management options.
The results were quite promising. We observed that CoQ10 significantly reduced the level of MMP-3 and improved various clinical outcomes—showing a notable drop in DAS-28 scores which indicates reduced disease activity. Furthermore, patients taking CoQ10 experienced significant reductions in swollen and tender joint counts, pain scores, and erythrocyte sedimentation rate (ESR) compared to their initial readings.
Overall, the findings suggest that CoQ10 supplementation may complement standard treatments for rheumatoid arthritis, helping to reduce inflammation and improve joint health. This new approach could offer hope for RA patients looking for additional management options.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosts energy
Excellent! I discovered IHERB products six months ago and now regularly order D3, also known as the solar vitamin. The small gelatin capsules are easy to take, and I drink two each morning. I've experienced no side effects during my use, and I've begun to feel much better overall, with increased vivacity and energy.
Read More
2
No visible results
I took the course but didn't see any noticeable effect, so I've decided to order from another company.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Salekzamani S, Pakkhesal S, Babaei M, Mirzaaghazadeh E, Mosaddeghi-Heris R, et al. Coenzyme Q10 supplementation in multiple sclerosis; A systematic review. Mult Scler Relat Disord. 2025;93:106212. doi:10.1016/j.msard.2024.106212
- Sun L, Xiao H, Ren Y, Xu K, Zhong X, et al. [Clinical and genetic analysis of a child with co-morbid progressive IgA nephropathy and COQ8B-associated glomerulopathy]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2024;41:1231. doi:10.3760/cma.j.cn511374-20240305-00144
- Poznyak AV, Orekhov NA, Churov AV, Starodubtseva IA, Beloyartsev DF, et al. Mitochondrial Dysfunction in Systemic Lupus Erythematosus: Insights and Therapeutic Potential. Diseases. 2024;12. doi:10.3390/diseases12090226
- Freire de Carvalho J, Skare T. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review. Clin Nutr ESPEN. 2024;59:63. doi:10.1016/j.clnesp.2023.11.016
- Hossein Haghighi A, Ahmadi A, Carotenuto A, Askari R, Nikkhah K, et al. Effects of concurrent training and CoQ10 on neurotrophic factors and physical function in people with Multiple Sclerosis: a pilot study. Eur J Transl Myol. 2023;33. doi:10.4081/ejtm.2023.11253
- Abdelkader HA, Rashed LA, Assaad E, Saleh MA. Serum and tissue levels of coenzyme Q10 in pemphigus vulgaris. J Cosmet Dermatol. 2022;21:3002. doi:10.1111/jocd.14511
- Kucharská J, Poništ S, Vančová O, Gvozdjáková A, Uličná O, et al. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiol Res. 2021;70:723.
- López-Pedrera C, Villalba JM, Patiño-Trives AM, Luque-Tévar M, Barbarroja N, et al. Therapeutic Potential and Immunomodulatory Role of Coenzyme Q and Its Analogues in Systemic Autoimmune Diseases. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10040600
- Kour G, Haq SA, Bajaj BK, Gupta PN, Ahmed Z. Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends. Pharmacol Res. 2021;169:105618. doi:10.1016/j.phrs.2021.105618
- Khalilian B, Madadi S, Fattahi N, Abouhamzeh B. Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis. J Mol Histol. 2021;52:125. doi:10.1007/s10735-020-09929-x
- Jhun J, Moon J, Ryu J, Shin Y, Lee S, et al. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One. 2020;15:e0241080. doi:10.1371/journal.pone.0241080
- Marx W, Hockey M, McGuinness AJ, Lane M, Christodoulou J, et al. The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review. Mult Scler Relat Disord. 2020;37:101486. doi:10.1016/j.msard.2019.101486
- Blanco LP, Pedersen HL, Wang X, Lightfoot YL, Seto N, et al. Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone. Arthritis Rheumatol. 2020;72:454. doi:10.1002/art.41128
- Nachvak SM, Alipour B, Mahdavi AM, Aghdashi MA, Abdollahzad H, et al. Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Clin Rheumatol. 2019;38:3367. doi:10.1007/s10067-019-04723-x
